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Updated: 2 hours 13 min ago

Uncertainty and Surprise Jointly Predict Musical Pleasure and Amygdala, Hippocampus, and Auditory Cortex Activity

Thu, 11/07/2019 - 00:00
Cheung et al. use a machine-learning model to mathematically quantify the predictive uncertainty and surprise of 80,000 chords in 745 commercially successful pop songs. The authors further show that chord uncertainty and surprise jointly modulate musical pleasure, as well as activity in the amygdala, hippocampus, and auditory cortex using fMRI.

Coordinated Behavioral and Physiological Responses to a Social Signal Are Regulated by a Shared Neuronal Circuit

Thu, 11/07/2019 - 00:00
Aprison and Ruvinsky identify a neuronal circuit required for the germline of C. elegans hermaphrodites to respond to a male pheromone. The same circuit mediates reduced exploratory movement in response to the pheromone. Shared reliance on the same signaling mechanism coordinates multiple pheromone responses that promote reproductive success.

Dynamic Regulation of Adult-Specific Functions of the Nervous System by Signaling from the Reproductive System

Thu, 11/07/2019 - 00:00
Aprison and Ruvinsky demonstrate that a retrograde signal from the vulva is required to permit adult-specific responses of C. elegans hermaphrodites to a male pheromone. The underlying circuit continuously apprises the nervous system regarding egg laying to match reproductive output with an appropriate behavioral repertoire.

Target-wide Induction and Synapse Type-Specific Robustness of Presynaptic Homeostasis

Thu, 11/07/2019 - 00:00
Genç and Davis interrogate the synapse specificity of presynaptic homeostasis, demonstrating that all synapses at which postsynaptic neurotransmitter receptors are perturbed express PHP, thereby supporting a global induction mechanism. However, different synapse types contacting a single target can differentially express homeostatic plasticity.

Cell-Cycle Asynchrony Generates DNA Damage at Mitotic Entry in Polyploid Cells

Thu, 11/07/2019 - 00:00
Nano et al. show that multinucleated polyploid cells can proceed through the cell cycle in an asynchronous manner. Delayed nuclei that are not yet competent to enter mitosis undergo DNA damage when exposed to the mitotic environment of neighboring nuclei. DNA damage can be attenuated by forcing cell-cycle synchronization.

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